Cover Story

How can we cure genetic diseases?

SPACE Lab develops context-aware genome editing technologies and hPSC-based disease modeling technologies, by combining genome engineering, human pluripotent stem cells, and generative AI.

Ju-Chan Park, Principal Investigator — Synthetic & Programmable Advanced Cell Engineering Lab, GSMSE, KAIST

Featured Publication

"AI-generated MLH1 small binder improves prime editing efficiency"

J.C. Park et al. · Cell · 2025

Featured Publication

"Enhancing Genome Editing in hPSCs through Dual Inhibition of DNA Damage Response and Repair Pathways"

J.C. Park et al. · Nature Communications · 2024

Featured Publication

"Multiple isogenic GNE-myopathy modeling with mutation specific phenotypes from human pluripotent stem cells by base editors"

J.C. Park et al. · Biomaterials · 2022

Two Directions Toward an Answer

Research

01

Cell & Gene Therapy

Context-aware genome editing tools — tailored to each cellular context for greater precision, efficiency, and safety.

02

Disease Modeling & Drug Discovery

A variomics platform built on human pluripotent stem cells — modeling genetic disease and powering mutation-specific drug discovery.

Built on Genome Engineering Generative AI Human Pluripotent Stem Cells

Members People →

Ju-Chan Park

Principal Investigator

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M.S.–Ph.D. Course

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Undergraduate Intern

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